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KMID : 0376219800170010085
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Chonnam Medical Journal
1980 Volume.17 No. 1 p.85 ~ p.90
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Synergism of Sufamethoxazole and Trimethoprim against Chloramphenicol-resistant Salmonella typhi
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Abstract
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A S. typhi strain which was highly resistant to chloramphenicol (CM) was selected among a number of samonella strains isolated at Chonnam University Hospital to be the present experiment investigating which combination of antibiotics would bring about the synergistic effect on the organism.
Trimethoprim-sulfamethoxazole (TPM-SMZ), ampicillin (AP) and CM were the choice of drug tested.
Checkerboard dilution method was applied to check the effect of drugs combined and synergism is defined as that FICI value is less than 0.9 (rather than 0.5), the line in isobologram being curved downward.
The result obtained were as follows.
1. The combined action of CM and TMP-SMZ was moderately synergistic, FIC of CM and TMP-SMZ being 0.5 and 0.125, respectively, and FICI 0.625.
2. Even when CM and Al´ were applied together the results same as above, i.e., FICs of each agent were, 0.5 and 0.125, FICI being 0.625.
3. Cooperation between TMP-SMZ and AP, however, did not bring about any synergistic effect, F1CI being 1.0
4. Thus it was suggested that combinations of CM with TMP-SMZ or with AP may have a synergistic effect on CM-resistant S. typhi strains.
5. The mechanism of synergism is so complicated that the present results may be too simple to conclude any definite benefits be applied clinically.
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